Hair Loss Treatment

Hair Loss Treatment at the Proctor Clinic

Cell Sci. 1990;97:463.

Human hair growth in vitro.
Philpott MP, et al

We report for the first time the successful maintenance and regrowth of human hair follicles in vitro. Human anagen hair follicles were isolated by microdissection from human scalp skin. Isolation of the hair follicles was achieved by cutting the follicle at the dermo-subcutaneous fat interface using a scalpel blade. Intact hair follicles were then removed from the fat using watchmakers’ forceps. Isolated hair follicles maintained free-floating in supplemented Williams E medium in individual wells of 24-well multiwell plates showed a significant increase in length over 4 days. The increase in length was seen to be attributed to the production of a keratinised hair shaft, and was not associated with the loss of hair follicle morphology. …snip…

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European Journal of Dermatology. Volume 11, Number 4, 293-5, July – August 2001, Articles de la revue
Author( : S. Andersson,

The gonadal synthesis of testosterone from cholesterol involves cytochrome P-450 side-chain cleavage enzyme, cytochrome P-450 17a-hydroxylase, 3b-hydroxysteroid dehydrogenase, and 17b-hydroxysteroid dehydrogenase. A significant part of testosterone is converted in androgen target tissues to the more potent androgen dihydrotestosterone by the steroid 5a-reductase isoenzymes. Dihydrotestosterone, which binds to the nuclear androgen receptor with much greater affinity than testosterone, is the androgen responsible for male pattern hair loss. Consequently, the 5a-reductase inhibitor finasteride was developed and has proven efficacious in promoting hair regrowth. Likewise, C19-steroids produced by glandular and peripheral tissues may also feed into skin production of dihydrotestosterone, oxidative 3a-hydroxysteroid dehydrogenase, and 3b-hydroxysteroid dehydrogenase enzymes. Aberrant expression of one or more of these enzymes could conceivably result in increased scalp dihydrotestosterone levels, acceleration of the balding process in men and women.